https://www.smithlabucsf.com/research daily 0.75 2022-01-11 https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1569894389469-P1MGEZCPU5A9T4MVI2YZ/image-asset.jpeg Research - Resistance to Targeted Therapeutics While FLT3 ITD mutations are widely implicated in therapeutic-resistant AML, there are many other resistance mutations that are understudied. Taking a multi-lens approach, we aim to characterize the genetic, molecular, and biochemical basis of resistance mutations to FLT3 inhibitors. We study both mutations both upstream and downstream of FLT3 in hopes to inform the next generation of cancer therapy. https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1569895110511-8U08MTSKNZDRN9F08VUT/image-asset.jpeg Research - Single Cell Sequencing We are partnering with Mission Bio to examine AML cell populations at the single cell level. By sequencing at the single cell level, we can examine co-mutations that arise throughout various time courses of treatment, allowing us to interrogate the evolutionary changes associated with the pressures of targeted therapeutics. https://www.smithlabucsf.com/home daily 1.0 2022-01-11 https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571628391572-LL6BKJ5KTZ4MUY3PM5YQ/image-asset.jpeg Home https://www.smithlabucsf.com/new-index-1 daily 0.75 2025-06-10 https://www.smithlabucsf.com/our-team-2 daily 0.75 2019-09-30 https://images.squarespace-cdn.com/content/v1/56e049e08a65e26059119cd5/1458588063381-MV9V3U1AXWYHYWKU5MDO/image-asset.jpeg Copy of Our Team https://images.squarespace-cdn.com/content/v1/56e049e08a65e26059119cd5/1458588087399-JQOKVAV0Y6T745O8WVT8/image-asset.jpeg Copy of Our Team https://images.squarespace-cdn.com/content/v1/56e049e08a65e26059119cd5/1458588118102-HOES79BWOVPLIJ4IF9IR/image-asset.jpeg Copy of Our Team https://www.smithlabucsf.com/about-intro daily 0.75 2019-09-28 https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1569695097760-Y3O0QG27B4K4Y26PTJX0/image-asset.jpeg About Intro https://www.smithlabucsf.com/our-mission-and-goals daily 0.75 2019-09-30 https://www.smithlabucsf.com/people daily 0.75 2024-08-08 https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/6e8eeca2-0fa9-49d0-849e-908d1a4fa287/_DSC8798_Original.jpg People - Isabelle Lomeli, BS Junior Specialist Isabelle.Lomeli@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/e96c24fe-895d-4e4d-9c76-560ee78a2e6e/portariat-06167.jpg People - Bogdan Popescu, MD, PhD Postdoctoral Scholar Bogdan.Popescu@uscf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/288bc43a-9cce-4d09-988f-50780a1ae533/Natalia+Murad.jpg People - Natália Murad, PhD Specialist Natalia.Murad@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/23e833ae-6ccb-49c5-8c4b-2c4e0bb949f9/IDpic.jpg People - Anushka Walia, BS Medical Student/Volunteer Anushka.Walia@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/fe80382e-148d-4c02-bb81-784d20ffc931/IMG_5588.jpg People - Andrew Koh, BA Junior Specialist Andrew.Koh@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/2b496225-9082-49e1-821e-3bc84093597b/NT_headshot.jpg People - Natalie Tantisira Volunteer Natalie.Tantisira@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/be2333e9-ba12-44d9-a5e2-eea8c5f4b573/peretz-headshot+copy.jpg People - Cheryl Peretz, MD Assistant Professor Cheryl.Peretz@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/fbde283e-019d-4703-be98-f23073a3728e/thumbnail_image.jpg People - Timothy Ferng, MD Assistant Professor Timothy.Ferng@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/684a0690-058b-45de-aa0e-1eaf56af4820/image0+%281%29.jpg People - Nikki Lei, BS Data Analyst Nikki.Lei@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/c1f25d38-d654-4238-9b16-bae6f1cbd9db/20180622_PSOMMJones_6+%281%29.jpg People - Matthew Jones, MD, DPhil Postdoctoral Scholar Matthew.Jones2@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/32a0f46b-727d-4244-8e50-4fddbab4ca43/Headshot.jpg People - Vanessa Kennedy, MD Postdoctoral Scholar Vanessa.Kennedy@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/7e31be36-7880-4271-9984-00098c85a95a/IMG_8697.jpg People - Elaine Tran, BS Junior Specialist/Lab Manager Elaine.Tran@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/786cc9ce-fcaa-4573-8640-9391c903930a/ayq_5197a.jpg People - Catherine Smith, MD Principle Investigator Department of Medicine, Division of Hematology and Oncology Primary Affiliation: Cancer Biology & Cell Signaling Secondary Affiliation: Human Genetics Catherine.Smith@ucsf.edu https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/b6b6692f-adce-4453-b8e1-9254574f2844/Madison+Piao.jpg People - Madison Piao Volunteer mpiao08@berkeley.edu https://www.smithlabucsf.com/publications-1 daily 0.75 2019-10-01 https://www.smithlabucsf.com/lab-fun daily 0.75 2024-08-08 https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571981451964-R5U8M8BMQAM6UZNMPEK3/Baseball.jpg Lab Fun https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571981526356-JBQZTT9EHEXMYK3QRDSU/Spark.jpg Lab Fun https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571981425773-O02FZ966N57OYJL4KYAC/20170728_1.JPG Lab Fun https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571981435106-VPTF1YITQH6I6QZX1UK9/20170728_2.JPG Lab Fun https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571981444802-CHHAAJSO7J51PRGVNS2P/20170728_7-2.JPG Lab Fun https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571981425061-2EMS4WJ63QK7VJUUL28S/001.jpg Lab Fun https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571981453381-WM1CSESKLFU1ZCTWBZ7O/IMG_0935-2.JPG Lab Fun https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571977408955-7LE9Z55Z5NLHUY9RAWPX/Spark.jpg Lab Fun - spark social 7/19/2019 After our meeting at Mission Bay, we decided to have a fun Friday and stick around for some food (and the sun) https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571980814457-6OM87I6SHLZ0JRIEF5F9/20170728_7-2.JPG Lab Fun - soooo many updates! Spring/Early Summer 2019 Our current junior specialist Lisa is leaving for Cornell to start her journey as a physician scientist. Also, our academic analyst Jimmy is leaving for another department! While we wish them the best, we will miss them a lot. However, our new junior specialist, Tanya, is starting in late June! We are excited to welcome her :) https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/359f8818-9fd9-4758-80e3-98a5a57bec07/Screen+Shot+2024-08-08+at+2.53.48+PM.jpg Lab Fun - graduation! 7/25/2024 Congratulations to Tim for transitioning to full-time clinical work and to Bogdan for successfully defending his PhD! https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/05a1f86c-39c9-42bc-bb80-83cfaac45a68/Screen+Shot+2024-08-08+at+2.42.22+PM.png Lab Fun - giants game! 8/12/2022 We went to a Giants game to celebrate the end of the summer! https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571976792208-PWVLH009IP4W50YV2QT5/001.jpg Lab Fun - it’s ugly sweater time… 12/20/2018 We had our annual holiday party at Cathy’s house! Of course, ugly sweaters were a must :) https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/5c550c32-b828-4f89-a163-4048650a83fd/holidaylunchdec2021.jpeg Lab Fun - holiday lunch 11/2021 We went to Fresca for our end-of-year celebration! https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571979117440-ZOG1PLR6DLKEJ3M6PRLZ/image-asset.jpeg Lab Fun - take me out to the ball game 8/31/2019 We went to a Giants game at the Oracle Arena and had some good food (especially the fries!!!), making it fun for sports fans and foodies alike https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/1571976537811-DWUEO8KFOFBBSM8JC6KU/IMG_0935-2.JPG Lab Fun - happy halloween! 10/31/2018 We had an awesome halloween turnout- everyone dressed up! https://www.smithlabucsf.com/publications daily 0.75 2025-09-16 https://images.squarespace-cdn.com/content/v1/5d8fa4eb56d2ec1659e6cfb2/f9265dbf-5aee-4716-8651-734166676007/Slide1.jpg Publications